Molecular Biology of Malignant Brain Tumors (<Special Issue>Topics of Malignant Brain Tumors)

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Malignant Brain Tumors in Childhood

Although most brain tumors are sporadic, a number of pediatric brain tumor presentations are associated with recognized genetic syndromes. About 15–20% of children with neurofibromatosis (NF1) present with CNS neoplasms, usually gliomas of the optic pathways or low-grade tumors of the diencephalon, cerebral hemispheres, or posterior fossa (2). Low-grade gliomas associated with NF1 may be less a...

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PATTERN OF MALIGNANT TUMORS IN KERMAN PROVINCE

From March 1980 to March 1989 a total number of 2254 (7.6%) new malignant cases from Kerman province were diagnosed by examination of surgical specimens, blood films and bone marrow smears. The crude relative frequency of cancers was studied and compared with other areas of Iran. Gastric (11.36%) and urinary bladder (7.01 %) carcinomas were significantly more common in Kerman province than...

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F-fluorothymidine kinetics of malignant brain tumors

Purpose F-labeled deoxy-fluorothymidine (FLT), a marker of cellular proliferation, has been used in PET tumor imaging. Here, the FLT kinetics of malignant brain tumors were investigated. Methods Seven patients with high-grade tumors and two patients with metastases had 12 studies. After 1.5 MBq/kg F-FLT had been administered intravenously, dynamic PET studies were acquired for 75 min. Images we...

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Chemotherapy for malignant brain tumors of childhood.

During the past 3 decades, chemotherapeutic agents for the treatment of pediatric brain tumors have been extensively evaluated in a myriad of schedules, doses, and combinations. Remarkable advances in outcome have been achieved for certain children, notably those with medulloblastoma, but with a high cost to quality of life. In addition, the success achieved for medulloblastoma is offset by lac...

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Photodynamic Therapy for Malignant Brain Tumors

Photodynamic therapy (PDT) using talaporfin sodium together with a semiconductor laser was approved in Japan in October 2003 as a less invasive therapy for early-stage lung cancer. The author believes that the principle of PDT would be applicable for controlling the invading front of malignant brain tumors and verified its efficacy through experiments using glioma cell lines and glioma xenograf...

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ژورنال

عنوان ژورنال: Japanese Journal of Neurosurgery

سال: 1997

ISSN: 0917-950X,2187-3100

DOI: 10.7887/jcns.6.306